Article
Hereditary cutaneous melanoma.
Seminars in cancer biology - 1 Aug 2000
Platz A, Ringborg U, Hansson J
Abstract excerpt
Members of some kindreds have a hereditary predisposition for development of cutaneous melanoma. Cytogenetic and linkage studies implicated chromosomes 1p and 9p as possible locations for genetic alterations predisposing for melanoma. Germline mutations in the CDKN2A gene on chromosome 9p21 have been identified in hereditary melanoma, but are present in only approximately 40% of kindreds with linkage to 9p21,...
Topics
- Chromosome Mapping
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 9
- Disease Susceptibility
- Genes, p16
- Humans
- Loss of Heterozygosity
- Melanoma
- Mutation
- Neoplastic Syndromes, Hereditary
- Risk Factors
- Skin Neoplasms