High- and low-penetrance cutaneous melanoma susceptibility genes.

Abstract excerpt

The aim of this review is to report the current understanding of the molecular genetics of melanoma predisposition. To date, two high-penetrance melanoma susceptibility genes, cyclin-dependent kinas inhibitor (CDKN)2A on chromosome 9p21 and cyclin-dependent kinase (CDK4) on 12q13, have been identified. Germline inactivating mutations of the CDKN2A gene are the most common cause of inherited susceptibility to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cyclin-Dependent Kinase 4
• Share to DNA Damage
• Share to Genes, p16