Article
Lack of mutation in the WAF1/CIP1 gene during bovine leukemia virus-induced leukemogenesis.
Veterinary immunology and immunopathology - 1 Nov 1997
Dequiedt F, Willems L, Kerkhofs P, Burny A, Kettmann R
Abstract excerpt
As a cyclin-dependent kinases (Cdks) inhibitor (CDI), the protein p21WAF1/CIP1 is able to interfere with cell cycle progression. Its expression is upregulated by wild-type p53, and the p21WAF1/CIP1 protein appears to be a potent effector of the p53-dependent cell cycle regulatory pathway. We have previously reported that p53 mutations frequently occur during bovine leukemia virus (BLV)-induced leukemogenesis in...
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