Article
Temporally regulated overexpression of parathyroid hormone-related protein in the mammary gland reveals distinct fetal and pubertal phenotypes.
The Journal of endocrinology - 1 Dec 2001
Dunbar M E, Dann P, Brown C W, Van Houton J, Dreyer B, Philbrick W P, Wysolmerski J J
Abstract excerpt
We have previously demonstrated that overexpression of parathyroid hormone-related protein (PTHrP) in the mammary glands of transgenic mice results in defects in ductal elongation and branching during puberty and in lobuloalveolar development during pregnancy. In addition, we have shown that PTHrP is necessary for the formation of the initial ductal tree during embryonic mammary development. In order to examine...
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