Article
Polymorphism of debrisoquine and mephenytoin hydroxylation among Estonians.
Pharmacology & toxicology - 1 Feb 1993
Kiivet R A, Svensson J O, Bertilsson L, Sjöqvist F
Abstract excerpt
Debrisoquine and S-mephenytoin hydroxylation polymorphisms were studied in 156 unrelated native Estonians. The hydroxylation phenotypes were assessed by coadministration of mephenytoin with debrisoquine or dextromethorphan. The frequency of the poor metaboliser phenotype of debrisoquine/dextromet...
Topics
- Adult
- Chromatography, Gas
- Chromatography, High Pressure Liquid
- Debrisoquin
- Dextromethorphan
- Estonia
- Female
- Humans
- Hydroxylation
- Male
- Mephenytoin
- Phenotype
- Polymorphism, Genetic