Debrisoquine and mephenytoin oxidation in Sinhalese: a population study.

doi:10.1111/j.1365-2125.1994.tb04384.x

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Article

Debrisoquine and mephenytoin oxidation in Sinhalese: a population study.

British journal of clinical pharmacology - 1 Nov 1994

Weerasuriya K, Jayakody R L, Smith C A, Wolf C R, Tucker G T, Lennard M S

Abstract excerpt

The frequency distributions of the 0-8 h urinary metabolic ratios of debrisoquine and mephenytoin were measured in 111 healthy, unrelated Sinhalese resident in Sri Lanka. Blood samples were taken from 77 of these subjects for CYP2D6 genotyping. Bimodality in the distribution of the log10 debrisoq...

Topics

Adult
Asian People
Cohort Studies
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Debrisoquin
Ethnicity
Female
Gene Expression Regulation, Enzymologic
Genotype
Heterozygote
Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Mephenytoin

Middle Aged

Mixed Function Oxygenases

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 7893590
DOI: 10.1111/j.1365-2125.1994.tb04384.x
PMCID: PMC1364882

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7893590-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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