Article
Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin.
Clinical pharmacology and therapeutics - 1 Apr 1992
Bertilsson L, Lou Y Q, Du Y L, Liu Y, Kuang T Y, Liao X M, Wang K Y, Reviriego J, Iselius L, Sjöqvist F
Abstract excerpt
The frequency of poor metabolizers of debrisoquin was low and similar in four different native Chinese nationalities. In a total sample of 695 Chinese subjects, only seven (1.01%) had a urinary ratio between debrisoquin and 4-hydroxydebrisoquin greater than 12.6, which is the antimode between poor metabolizers and extensive metabolizers in white populations. This is significantly lower than the 6.82% found in...
Topics
- China
- Chromatography, Gas
- Debrisoquin
- Humans
- Hydroxylation
- Mephenytoin
- Phenotype
- Polymorphism, Genetic
- Sweden