Article
An altered intron inhibits synthesis of the acetylcholine receptor alpha-subunit in the paralyzed zebrafish mutant nic1.
Genetics - 1 Jan 1998
Sepich D S, Wegner J, O'Shea S, Westerfield M
Abstract excerpt
The acetylcholine receptor (AChR), an oligomeric protein composed of five subunits, is a component of the postsynaptic membrane at the vertebrate neuromuscular junction that plays a central role in synaptic transmission. The zebrafish mutation nic1 blocks the expression of functional and clustere...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Gene Deletion
- Introns
- Molecular Sequence Data
- Paralysis
- Phenotype
- Polymorphism, Restriction Fragment Length
- RNA, Messenger
- Receptors, Cholinergic
- Sequence Alignment
- Sequence Homology, Amino Acid
- Sequence Homology, Nucleic Acid
- Zebrafish