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Article

An altered intron inhibits synthesis of the acetylcholine receptor alpha-subunit in the paralyzed zebrafish mutant nic1.

Genetics - 1 Jan 1998

Sepich D S, Wegner J, O'Shea S, Westerfield M

Abstract excerpt

The acetylcholine receptor (AChR), an oligomeric protein composed of five subunits, is a component of the postsynaptic membrane at the vertebrate neuromuscular junction that plays a central role in synaptic transmission. The zebrafish mutation nic1 blocks the expression of functional and clustered nicotinic muscle AChRs. To understand the mechanisms underlying this lack of AChRs, we characterized the molecular...

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Identifiers

PMID: 9475746
DOI: 10.1093/genetics/148.1.361
PMCID: PMC1459800

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