Article
Acetylcholinesterase is required for neuronal and muscular development in the zebrafish embryo.
Nature neuroscience - 1 Feb 2002
Behra Martine, Cousin Xavier, Bertrand Christelle, Vonesch Jean-Luc, Biellmann Dominique, Chatonnet Arnaud, Strähle Uwe
Abstract excerpt
The neurotransmitter acetylcholine (ACh) has a crucial role in central and neuromuscular synapses of the cholinergic system. After release into the synaptic cleft, ACh is rapidly degraded by acetylcholinesterase (AChE). We have identified a mutation in the ache gene of the zebrafish, which abolishes ACh hydrolysis in homozygous animals completely. Embryos are initially motile but subsequently develop paralysis....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.