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Article

A modified acetylcholine receptor delta-subunit enables a null mutant to survive beyond sexual maturation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Dec 2008

Epley Kimberly E, Urban Jason M, Ikenaga Takanori, Ono Fumihito

Abstract excerpt

The contraction of skeletal muscle is dependent on synaptic transmission through acetylcholine receptors (AChRs) at the neuromuscular junction (NMJ). The lack of an AChR subunit causes a fetal akinesia in humans, leading to death in the first trimester and characteristic features of Fetal Akinesia Deformation Sequences (FADS). A corresponding null mutation of the delta-subunit in zebrafish (sofa potato; sop)...

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Share to Acetylcholine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neuromuscular Junction

Share to Receptors, Cholinergic

Share to Sexual Behavior, Animal

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Source

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Identifiers

PMID: 19052214
DOI: 10.1523/JNEUROSCI.2814-08.2008
PMCID: PMC2679261

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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