Article
Increased neuromuscular activity causes axonal defects and muscular degeneration.
Development (Cambridge, England) - 1 Jun 2004
Lefebvre Julie L, Ono Fumihito, Puglielli Cristina, Seidner Glen, Franzini-Armstrong Clara, Brehm Paul, Granato Michael
Abstract excerpt
Before establishing terminal synapses with their final muscle targets, migrating motor axons form en passant synaptic contacts with myotomal muscle. Whereas signaling through terminal synapses has been shown to play important roles in pre- and postsynaptic development, little is known about the function of these early en passant synaptic contacts. Here, we show that increased neuromuscular activity through en...
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