Article
Alternative splicing leads to two cholinergic proteins in Caenorhabditis elegans.
Journal of molecular biology - 26 Aug 1994
Alfonso A, Grundahl K, McManus J R, Asbury J M, Rand J B
Abstract excerpt
The cha-1 gene of Caenorhabditis elegans encodes choline acetyl-transferase (the acetylcholine synthetic enzyme). The C. elegans unc-17 gene encodes a synaptic vesicle-associated acetylcholine transporter. The two genes thus define sequential biochemical steps in the metabolism of the neurotransmitter acetylcholine. Cloning, sequencing, and molecular analysis of the unc-17 region indicate that cha-1 and unc-17...
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