Article
Alternative splicing leads to two cholinergic proteins in Caenorhabditis elegans.
Journal of molecular biology - 26 Aug 1994
Alfonso A, Grundahl K, McManus J R, Asbury J M, Rand J B
Abstract excerpt
The cha-1 gene of Caenorhabditis elegans encodes choline acetyl-transferase (the acetylcholine synthetic enzyme). The C. elegans unc-17 gene encodes a synaptic vesicle-associated acetylcholine transporter. The two genes thus define sequential biochemical steps in the metabolism of the neurotransmitter acetylcholine. Cloning, sequencing, and molecular analysis of the unc-17 region indicate that cha-1 and unc-17...
Topics
- Alleles
- Alternative Splicing
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Carrier Proteins
- Choline O-Acetyltransferase
- Exons
- Helminth Proteins
- Molecular Sequence Data
- Mutation