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Article

Microglial activation and neuronal apoptosis in Bornavirus infected neonatal Lewis rats.

Brain pathology (Zurich, Switzerland) - 1 Apr 2000

Weissenböck H, Hornig M, Hickey W F, Lipkin W I

Abstract excerpt

Lewis rats neonatally infected with Borna disease virus have a behavioral syndrome characterized by hyperactivity, movement disorders, and abnormal social interactions. Virus is widely distributed in brain; however, neuropathology is focused in dentate gyrus, cerebellum, and neocortex where granule cells, Purkinje cells and pyramidal cells are lost through apoptosis. Although a transient immune response is...

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Identifiers

PMID: 10764045
DOI: 10.1111/j.1750-3639.2000.tb00259.x
PMCID: PMC8098497

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