Article
FcgammaRIIA polymorphisms in Streptococcus pneumoniae infection.
Immunology and cell biology - 1 Jun 2003
Yuan Fang Fang, Wong Melanie, Pererva Natalia, Keating Joanna, Davis Andrew R, Bryant Jenny A, Sullivan John S
Abstract excerpt
Invasive pneumococcal disease continues to be a major cause of morbidity and mortality among children and adults worldwide. Effective host defence against Streptococcus pneumoniae depends on immunoglobulin G-mediated phagocytosis of the bacteria and it has been shown in vitro that the FcgammaRIIA polymorphism (FcgammaRIIA-R131 vs FcgammaRIIA-H131) determines the capacity of immunoglobulin G2-mediated phagocytosis...
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