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Article

Asymptomatic dengue infection in a Cuban population confirms the protective role of the RR variant of the FcgammaRIIa polymorphism.

The American journal of tropical medicine and hygiene - 1 Jun 2010

García Gissel, Sierra Beatriz, Pérez Ana B, Aguirre Eglys, Rosado Ileana, Gonzalez Narjara, Izquierdo Alienys, Pupo Maritza, Danay Díaz Didye Ruiz, Sánchez Lizet, Marcheco Beatriz, Hirayama Kenji, Guzmán María G

Abstract excerpt

The role of human Fcgamma receptors (FcgammaR) has been recognized considerably over the last years. These receptors vary in their affinity for IgG subclasses and the intracellular signals elicited by them. Allelic variants of FcgammaR genes may influence the biological phagocyte activity, accounting for an inherited pre-disposition to disease. The specific FcgammaRIIa (CD32) contains a polymorphic variant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20519616
DOI: 10.4269/ajtmh.2010.09-0353
PMCID: PMC2877427

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