Article
Fcgamma receptor IIa polymorphism in Caucasian patients with systemic lupus erythematosus: association with clinical symptoms.
Arthritis and rheumatism - 1 Jul 1998
Manger K, Repp R, Spriewald B M, Rascu A, Geiger A, Wassmuth R, Westerdaal N A, Wentz B, Manger B, Kalden J R, van de Winkel J G
Abstract excerpt
OBJECTIVE: The class II human leukocyte Fcy receptor for IgG (FcgammaRIIa) occurs in 2 codominantly expressed allelic forms (R131 and H131). Cells expressing IIa-H131 interact much more effectively with complexed IgG2 and IgG3 than do cells with IIa-R131. This might be linked to variability in im...
Topics
- Adolescent
- Adult
- Age of Onset
- Aged
- Alleles
- Antigens, CD
- Child
- Female
- HLA-DR Antigens
- Hematologic Diseases
- Humans
- Immune System Diseases
- Lupus Erythematosus, Systemic
- Male
- Middle Aged
- Polymorphism, Genetic