Article
MDM2 suppresses p73 function without promoting p73 degradation.
Molecular and cellular biology - 1 May 1999
Zeng X, Chen L, Jost C A, Maya R, Keller D, Wang X, Kaelin W G, Oren M, Chen J, Lu H
Abstract excerpt
The newly identified p53 homolog p73 can mimic the transcriptional activation function of p53. We investigated whether p73, like p53, participates in an autoregulatory feedback loop with MDM2. p73 bound to MDM2 both in vivo and in vitro. Wild-type but not mutant MDM2, expressed in human p53 null osteosarcoma Saos-2 cells, inhibited p73- and p53-dependent transcription driven by the MDM2 promoter-derived p53RE...
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