Article
Locus-specific conservation of the HLA class I introns by intra-locus homogenization.
Immunogenetics - 1 Jan 1997
Cereb N, Hughes A L, Yang S Y
Abstract excerpt
The protein-coding sequences of the major histocompatibility complex (MHC) genes are characterized by extraordinarily high polymorphism, apparently maintained by balancing selection, which favors diversity in the peptide-binding domains of the MHC glycoproteins. Here we report that the introns fl...
Topics
- Alleles
- Animals
- Base Sequence
- Cell Line, Transformed
- Chromosome Mapping
- Conserved Sequence
- Exons
- Genes, MHC Class I
- HLA-A Antigens
- HLA-B Antigens
- HLA-C Antigens
- Humans
- Introns
- Mutagenesis
- Pan troglodytes
- Polymorphism, Genetic
- Recombination, Genetic