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Article

Locus-specific conservation of the HLA class I introns by intra-locus homogenization.

Immunogenetics - 1 Jan 1997

Cereb N, Hughes A L, Yang S Y

Abstract excerpt

The protein-coding sequences of the major histocompatibility complex (MHC) genes are characterized by extraordinarily high polymorphism, apparently maintained by balancing selection, which favors diversity in the peptide-binding domains of the MHC glycoproteins. Here we report that the introns flanking the polymorphic exons of the human MHC class I loci HLA-A, -B, and -C genes have been relatively conserved and...

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PMID: 9382918
DOI: 10.1007/s002510050323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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