Article
The nature of introns 4-6 suggests reduced lineage specificity in HLA-B alleles.
Genes and immunity - 1 Sept 2003
Elsner H-A, Baengeroth K, Blasczyk R
Abstract excerpt
For most HLA-B alleles, coding sequences of the 3' part of the genes still need to be determined, and sequences of the 3' noncoding regions have yet to be studied systematically. In this study, we have determined the sequences of introns 4-6 in all HLA-B allelic groups, and computed nucleotide substitution rates and phylogenetic relationships. These sequences demonstrated an inconsistent pattern of intralineage...
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