Mutational analysis of the transforming growth factor beta receptor type II gene in hereditary nonpolyposis colorectal cancer and early-onset colorectal cancer patients.

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Article

Mutational analysis of the transforming growth factor beta receptor type II gene in hereditary nonpolyposis colorectal cancer and early-onset colorectal cancer patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2000

Shin K H, Park Y J, Park J G

Abstract excerpt

Somatic mutations in the transforming growth factor beta receptor type II (TGF-beta RII) gene have been observed in various human cancers showing microsatellite instability. Most of the mutations observed were additions or deletions of the mononucleotide repeat sequence present in TGF-beta RII coding region, suggesting that the TGF-beta RII may be a target gene of genomic instability in tumorigenesis. Recently,...

Topics

Adult
Age of Onset
Codon
Colorectal Neoplasms
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Mutational Analysis
DNA, Neoplasm
Humans
Korea
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymerase Chain Reaction

Polymorphism, Genetic

Polymorphism, Single-Stranded Conformational

Protein Serine-Threonine Kinases

Receptor, Transforming Growth Factor-beta Type II

Receptors, Transforming Growth Factor beta

Repetitive Sequences, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 10690536

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Mutational analysis of the transforming growth factor beta receptor type II gene in hereditary nonpolyposis colorectal cancer and early-onset colorectal cancer patients.PMID 10690536Read ↗

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