Article
Mutation and expression analysis of the p27/kip1 gene in corticotrophin-secreting tumours.
Oncogene - 8 Jan 1998
Dahia P L, Aguiar R C, Honegger J, Fahlbush R, Jordan S, Lowe D G, Lu X, Clayton R N, Besser G M, Grossman A B
Abstract excerpt
The molecular mechanisms leading to Cushing's disease are unclear. Inhibitors of cyclin-cyclin dependent kinase (CDK) complexes are regulators of the cell cycle and may function as tumour suppressor genes, many of which have been involved in the pathogenesis of several human malignancies. A member of this family, the p27/kip1 gene, maps to chromosome 12p13 and encodes an inhibitor of several cyclin-CDK complexes;...
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