Human pheochromocytomas show reduced p27Kip1 expression that is not associated with somatic gene mutations and rarely with deletions.

doi:10.1007/s00428-007-0431-6

Article

Human pheochromocytomas show reduced p27Kip1 expression that is not associated with somatic gene mutations and rarely with deletions.

Virchows Archiv : an international journal of pathology - 1 Jul 2007

Pellegata Natalia S, Quintanilla-Martinez Leticia, Keller Gisela, Liyanarachchi Sandya, Höfler Heinz, Atkinson Michael J, Fend Falko

Abstract excerpt

Pheochromocytomas are neuroendocrine tumors arising in the neural crest-derived chromaffin cells of the adrenal gland or in extra-adrenal sympathetic ganglia (paragangliomas). In a rat model of multiple endocrine neoplasia (MEN), absence of functional p27Kip1 protein predisposes to pheochromocytoma and paraganglioma development. As no data is available regarding the involvement of p27Kip1 in human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Human pheochromocytomas show reduced p27Kip1 expression that is not associated with somatic gene mutations and rarely with deletions.

Abstract excerpt

Topics

Related research