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Article

p27(Kip1) deficiency causes organ of Corti pathology and hearing loss.

Hearing research - 1 Apr 2006

Kanzaki Sho, Beyer Lisa A, Swiderski Donald L, Izumikawa Masahiko, Stöver Timo, Kawamoto Kohei, Raphael Yehoash

Abstract excerpt

p27(Kip1) (p27) has been shown to inhibit several cyclin-dependent kinase molecules and to play a central role in regulating entry into the cell cycle. Once hair cells in the cochlea are formed, p27 is expressed in non-sensory cells of the organ of Corti and prevents their re-entry into the cell cycle. In one line of p27 deficient mice (p27(-/-)), cell division in the organ of Corti continues past its normal...

Read the complete abstract on PubMed

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Share to Cyclin-Dependent Kinase Inhibitor p27
Share to Evoked Potentials, Auditory, Brain Stem

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hair Cells, Auditory

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Share to Microscopy, Electron, Scanning

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Source

Identifiers

PMID: 16513305
DOI: 10.1016/j.heares.2006.01.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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