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Article

Mutational analysis of the cell cycle inhibitor Kip1/p27 in childhood leukemia.

Pediatric blood & cancer - 1 Jul 2006

Markaki E-A, Stiakaki E, Zafiropoulos A, Arvanitis D A, Katzilakis N, Dimitriou H, Spandidos D A, Kalmanti M

Abstract excerpt

BACKGROUND: Cyclin-dependent kinases (CDKs) and cyclins, their regulatory subunits, govern cell-cycle progression in eukaryotic cells. Kip1/p27 is the main cyclin-dependent kinase inhibitor, which arrests cell division inhibiting G1-S transition. Kip1/p27 seems to play a critical role in the pathogenesis of several human malignancies and its lower expression has been shown to correlate with a poor prognosis in...

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Identifiers

PMID: 16526056
DOI: 10.1002/pbc.20730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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