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Article

Cooperation between cyclin E and p27(Kip1) in pituitary tumorigenesis.

Molecular endocrinology (Baltimore, Md.) - 1 Sept 2010

Roussel-Gervais Audrey, Bilodeau Steve, Vallette Sophie, Berthelet France, Lacroix André, Figarella-Branger Dominique, Brue Thierry, Drouin Jacques

Abstract excerpt

Cushing's disease is caused by glucocorticoid-resistant pituitary corticotroph adenomas. We have previously identified the loss of nuclear Brg1 as one mechanism that may lead to partial glucocorticoid resistance: this loss is observed in about 33% of human corticotroph adenomas. We now show that Brg1 loss of function correlates with cyclin E expression in corticotroph adenomas and with loss of the cell cycle...

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Identifiers

PMID: 20660298
DOI: 10.1210/me.2010-0091
PMCID: PMC5417399

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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