Article
Mouse models of human familial cancer syndromes.
Toxicologic pathology - 1 Jan 2000
Ward Jerrold M, Devor-Henneman Deborah E
Abstract excerpt
As many as 5% of human cancers appear to be of hereditable etiology. Of the more than 50 characterized familial cancer syndromes, most involve disease affecting multiple organs and many can be traced to one or more abnormalities in specific genes. Studying these syndromes in humans is a difficult task, especially when it comes to genes that may manifest themselves early in gestation. It has been made somewhat...
Topics
- Animals
- Disease Models, Animal
- Female
- Genetic Predisposition to Disease
- Humans
- Mice
- Mice, Knockout
- Mice, Transgenic
- Neoplasms
- Neoplasms, Experimental
- Syndrome