Gene disruption in mice: models of development and disease.

doi:10.1023/a:1006865210012

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Article

Gene disruption in mice: models of development and disease.

Molecular and cellular biochemistry - 1 Apr 1998

Shastry B S

Abstract excerpt

Gene targeting technology in mice by homologous recombination has become an important method to generate loss-of-function of genes in a predetermined locus. Although the inactivation is limited to irreversible alteration of chromosomal DNA and a surprising variety of genes have given unexpected and disappointing results, modification of the basic technology now provides additional choices for a more specific and...

Topics

Animals
Disease Models, Animal
Embryonic and Fetal Development
Gene Targeting
Genes
Humans
Mice
Mice, Knockout
Models, Genetic
Mutation

Source

Open in PubMed

Identifiers

PMID: 9562253
DOI: 10.1023/a:1006865210012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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