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Article

Imprinting at the mouse Ins2 locus: evidence for cis- and trans-allelic interactions.

Genomics - 1 Jan 1998

Duvillié B, Bucchini D, Tang T, Jami J, Pàldi A

Abstract excerpt

The mouse gene encoding preproinsulin 2 (Ins2) is located on the distal end of chromosome 7 in a region of several hundred kilobases that contains several imprinted genes. The exclusive expression of the Ins2 paternal allele in the visceral yolk sac during the last part of gestation indicates that Ins2 also is imprinted. However, in other tissues in which Ins2 is expressed, both alleles are active at all...

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Identifiers

PMID: 9465295
DOI: 10.1006/geno.1997.5070

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