Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Paternal repression of the imprinted mouse Igf2r locus occurs during implantation and is stable in all tissues of the post-implantation mouse embryo.

Mechanisms of development - 1 Jan 1997

Lerchner W, Barlow D P

Abstract excerpt

The insulin-like growth factor type 2 receptor, also known as the cation independent mannose-6-phosphate receptor (Igf2r) is an imprinted gene, which is repressed on the paternally inherited allele in midgestation mouse embryos. We have used a LacZ reporter gene, targeted into the endogenous gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Fathers
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mothers

Share to Receptor, IGF Type 2

Source

Identifiers

PMID: 9076684
DOI: 10.1016/s0925-4773(96)00630-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9076684-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Paternal repression of the imprinted mouse Igf2r locus occurs during implantation and is stable in all tissues of the post-implantation mouse embryo.PMID 9076684Read ↗

Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr gene.Semantic proximity Read ↗

Igf2r and Igf2 gene expression in androgenetic, gynogenetic, and parthenogenetic preimplantation mouse embryos: absence of regulation by genomic imprinting.Semantic proximity Read ↗

An in vitro ES cell imprinting model shows that imprinted expression of the Igf2r gene arises from an allele-specific expression bias.Semantic proximity Read ↗

Non-imprinted Igf2r expression decreases growth and rescues the Tme mutation in mice.Semantic proximity Read ↗

Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality.Semantic proximity Read ↗

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signalSemantic proximity Read ↗

The imprinting box of the mouse Igf2r gene.Semantic proximity Read ↗

Tissue-specific imprinting of the mouse insulin-like growth factor II receptor gene correlates with differential allele-specific DNA methylation.Semantic proximity Read ↗

The insulin-like growth factor type-2 receptor gene is imprinted in the mouse but not in humans.Semantic proximity Read ↗

Allele-specific detection of nascent transcripts by fluorescence in situ hybridization reveals temporal and culture-induced changes in Igf2 imprinting during pre-implantation mouse development.Semantic proximity Read ↗

The histone code regulating expression of the imprinted mouse Igf2r gene.Semantic proximity Read ↗

Maternal transmission of a humanised Igf2r allele results in an Igf2 dependent hypomorphic and non-viable growth phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.