Article
Allele specific inactivation of insulin 1 and 2, in the mouse yolk sac, indicates imprinting.
Nature genetics - 1 Mar 1994
Giddings S J, King C D, Harman K W, Flood J F, Carnaghi L R
Abstract excerpt
Genomic imprinting, gene inactivation during gametogenesis, causes maternal and paternal alleles of some genes to function unequally. We examined the possibility of imprinting in insulin genes because the human insulin gene (ins) and its mouse homologue (ins2) are adjacent to the known imprinted genes, igf2 and H19, and because imprinting has been implicated in the transmission of an ins linked risk for Type I...
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