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Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32

15 Jul 2002

Abstract excerpt

Imprinted gene(s) on human chromosome 7 are thought to be involved in Russell-Silver syndrome (RSS), based on the fact that approximately 10% of patients have maternal uniparental disomy of chromosome 7. However, involvement of the known imprinted genes (GRB10 at 7p12, PEG10 at 7q21.3 and MEST at 7q32) in RSS has yet to be established. To screen for new imprinted genes, we are initially using somatic cell hybrids...

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Epigenetics and DNA Methylation
Genetic Syndromes and Imprinting
Prenatal Screening and Diagnostics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12095916
DOI: 10.1093/hmg/11.15.1743

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Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32PMID 12095916Read ↗

Monoallelic expression of human PEG1/MEST is paralleled by parent-specific methylation in fetuses.Semantic proximity Read ↗

An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa.Semantic proximity Read ↗

The gene TSGA14, adjacent to the imprinted gene MEST, escapes genomic imprinting.Semantic proximity Read ↗

Imprinting analysis of 10 genes and/or transcripts in a 1.5-Mb MEST-flanking region at human chromosome 7q32.Semantic proximity Read ↗

A 79-kb paternally inherited 7q32.2 microdeletion involving MEST in a patient with a Silver-Russell syndrome-like phenotype.Semantic proximity Read ↗

Tissue-specific alternative polyadenylation at the imprinted gene Mest regulates allelic usage at Copg2.Semantic proximity Read ↗

Genomic Structure and Parent-of-Origin-Specific Methylation of Peg1Semantic proximity Read ↗

Isoform-Specific Imprinting of the Human PEG1/MEST GeneSemantic proximity Read ↗

Peg1/Mest imprinted gene on chromosome 6 identified by cDNA subtraction hybridizationSemantic proximity Read ↗

Marsupials have monoallelic MEST expression with a conserved antisense lncRNA but MEST may not be imprinted.Semantic proximity Read ↗

No evidence of PEG1/MEST gene mutations in Silver-Russell syndrome patients.Semantic proximity Read ↗

Deletion of the paternal allele of the imprinted MEST/PEG1 region in a patient with Silver-Russell syndrome features.Semantic proximity Read ↗

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