Article
Lack of reciprocal genomic imprinting of sense and antisense RNA of mouse insulin-like growth factor II receptor in the central nervous system.
Biochemical and biophysical research communications - 13 Apr 1999
Hu J F, Balaguru K A, Ivaturi R D, Oruganti H, Li T, Nguyen B T, Vu T H, Hoffman A R
Abstract excerpt
Two models have been proposed to account for the molecular mechanism underlying genomic imprinting of the insulin-like growth factor II receptor gene (Igf2r): expression-competition and promoter DNA methylation. To examine which model best explains the regulation of Igf2r imprinting, we examined the allelic expression of endogenous Igf2r sense and antisense RNAs in mice. In peripheral tissues, Igf2r sense and...
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