Article
An in vitro ES cell imprinting model shows that imprinted expression of the Igf2r gene arises from an allele-specific expression bias.
Development (Cambridge, England) - 1 Feb 2009
Latos Paulina A, Stricker Stefan H, Steenpass Laura, Pauler Florian M, Huang Ru, Senergin Basak H, Regha Kakkad, Koerner Martha V, Warczok Katarzyna E, Unger Christine, Barlow Denise P
Abstract excerpt
Genomic imprinting is an epigenetic process that results in parental-specific gene expression. Advances in understanding the mechanism that regulates imprinted gene expression in mammals have largely depended on generating targeted manipulations in embryonic stem (ES) cells that are analysed in vivo in mice. However, genomic imprinting consists of distinct developmental steps, some of which occur in...
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