Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jan 1993

Deltour L, Leduque P, Blume N, Madsen O, Dubois P, Jami J, Bucchini D

Abstract excerpt

In the mouse, insulin is produced from two similar but nonallelic genes that encode proinsulins I and II. We have investigated expression of these two genes during mouse embryonic development, using a PCR to detect the two gene transcripts and immunocytochemistry to visualize the two corresponding proteins. At appearance of the dorsal pancreatic anlage at day 9.5 of gestation, both mRNAs could be detected in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression

Share to Immunohistochemistry

Share to Mice, Inbred C57BL

Share to Molecular Sequence Data

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 8421685
DOI: 10.1073/pnas.90.2.527
PMCID: PMC45696

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo.PMID 8421685Read ↗

Two nonallelic insulin genes in Xenopus laevis are expressed differentially during neurulation in prepancreatic embryos.Semantic proximity Read ↗

Onset of cell-specific gene expression in the developing mouse pancreas.Semantic proximity Read ↗

Imprinting at the mouse Ins2 locus: evidence for cis- and trans-allelic interactions.Semantic proximity Read ↗

Differential and tissue-specific regulation of (pro)insulin and insulin-like growth factor-I mRNAs and levels of thyroid hormones in growth-retarded embryos.Semantic proximity Read ↗

Insulin, insulin-like growth factors and glucose transporters: temporal patterns of gene expression in early murine and bovine embryosSemantic proximity Read ↗

Expression of mRNA for the insulin-like growth factors and their receptors in human preimplantation embryosSemantic proximity Read ↗

The two nonallelic insulin-like growth factor-I genes in Xenopus laevis are differentially regulated during development.Semantic proximity Read ↗

Differential expression of Ped gene candidates in preimplantation mouse embryos.Semantic proximity Read ↗

Expression of IGF‐I and insulin receptor genes in the rat central nervous system: A developmental, regional, and cellular analysisSemantic proximity Read ↗

Evidence that Xenopus laevis contains two different nonallelic insulin-like growth factor-I genes.Semantic proximity Read ↗

Molecular cloning and DNA sequence analysis of preproinsulin genes in the NON mouse, an animal model of human non-obese, non-insulin-dependent diabetes mellitus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.