Article
Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jan 1993
Deltour L, Leduque P, Blume N, Madsen O, Dubois P, Jami J, Bucchini D
Abstract excerpt
In the mouse, insulin is produced from two similar but nonallelic genes that encode proinsulins I and II. We have investigated expression of these two genes during mouse embryonic development, using a PCR to detect the two gene transcripts and immunocytochemistry to visualize the two correspondin...
Topics
- Alleles
- Animals
- Base Sequence
- Crosses, Genetic
- Gene Expression
- Immunohistochemistry
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Molecular Sequence Data
- Pancreas
- Proinsulin
- RNA, Messenger
- Tissue Distribution