Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective.

Hepatology (Baltimore, Md.) - 1 Feb 1998

Melegari M, Scaglioni P P, Wands J R

Abstract excerpt

Hepatitis B virus (HBV) variant strains may develop during therapy for chronic infection with the nucleoside analog 2',3'-dideoxy-3'-thiacytidine (3TC). HBV mutants result from isoleucine (I) or valine (V) substitutions in the methionine (M) of the YMDD motif in the viral reverse-transcriptase catalytic domain. In addition, other mutations in the reverse-transcriptase "B domain" involving either a phenylalanine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Blotting, Northern
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line

Share to Hepatitis B virus

Share to Liver Neoplasms

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 9462667
DOI: 10.1002/hep.510270243

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective.PMID 9462667Read ↗

Transient selection of a hepatitis B virus polymerase gene mutant associated with a decreased replication capacity and famciclovir resistance.Semantic proximity Read ↗

Functional analysis of mutations conferring lamivudine resistance on hepatitis B virus.Semantic proximity Read ↗

Identification and characterization of mutations in hepatitis B virus resistant to lamivudine. Lamivudine Clinical Investigation Group.Semantic proximity Read ↗

Mutation in HBV RNA-dependent DNA polymerase confers resistance to lamivudine in vivo.Semantic proximity Read ↗

APOBEC3B edits HBV DNA and inhibits HBV replication during reverse transcription.Semantic proximity Read ↗

Sensitivity of L-(-)2,3-dideoxythiacytidine resistant hepatitis B virus to other antiviral nucleoside analogues.Semantic proximity Read ↗

In vitro characterization of the anti-hepatitis B virus activity and cross-resistance profile of 2',3'-dideoxy-3'-fluoroguanosine.Semantic proximity Read ↗

Mutation in HBV RNA-dependent DNA polymerase confers resistance to lamivudine in vivoSemantic proximity Read ↗

Decreased infectivity of nucleoside analogs-resistant hepatitis B virus mutants.Semantic proximity Read ↗

Kinetic analysis of wild-type and YMDD mutant hepatitis B virus polymerases and effects of deoxyribonucleotide concentrations on polymerase activity.Semantic proximity Read ↗

Mutations in the hepatitis B virus polymerase gene associated with antiviral treatment for hepatitis B.Semantic proximity Read ↗

Characterization of Novel Human Hepatoma Cell Lines with Stable Hepatitis B Virus Secretion for Evaluating New Compounds against Lamivudine- and Penciclovir-Resistant VirusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.