Article
Transient selection of a hepatitis B virus polymerase gene mutant associated with a decreased replication capacity and famciclovir resistance.
Hepatology (Baltimore, Md.) - 1 Jan 1999
Pichoud C, Seignères B, Wang Z, Trépo C, Zoulim F
Abstract excerpt
Prolonged therapy for chronic hepatitis B (HBV) with nucleoside analogs may result in the emergence of HBV mutants resistant to antivirals. Here, we describe the transient selection of an HBV polymerase gene mutant that was associated with viral persistence in an immune competent patient treated...
Topics
- 2-Aminopurine
- Adult
- Amino Acid Sequence
- Antiviral Agents
- Biomarkers
- Cells, Cultured
- Cloning, Molecular
- DNA-Directed DNA Polymerase
- Drug Resistance, Microbial
- Famciclovir
- Hepatitis B virus
- Hepatitis B, Chronic
- Humans
- Immunocompetence
- Male
- Molecular Sequence Data
- Mutation
- Prodrugs