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Article

Sensitivity of L-(-)2,3-dideoxythiacytidine resistant hepatitis B virus to other antiviral nucleoside analogues.

Biochemical pharmacology - 15 Jun 1999

Fu L, Liu S H, Cheng Y C

Abstract excerpt

L-(-)2',3'-Dideoxythiacytidine (L(-)SddC, Lamivudine) resistant hepatitis B virus (HBV) develops in patients after prolonged treatment. Point mutations detected in the viral genome from these patients have been shown to be responsible for L(-)SddC resistance. Therefore, new drugs active against L(-)SddC resistant HBV are needed. Using a transient transfection system, we studied the sensitivity of L(-)SddC...

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Identifiers

PMID: 10353255
DOI: 10.1016/s0006-2952(99)00073-8

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