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Article

Kinetic analysis of wild-type and YMDD mutant hepatitis B virus polymerases and effects of deoxyribonucleotide concentrations on polymerase activity.

Antimicrobial agents and chemotherapy - 1 Apr 2002

Gaillard Richard K, Barnard Jennifer, Lopez Vincent, Hodges Paula, Bourne Eric, Johnson Lance, Allen Marchelle I, Condreay Patrick, Miller Wayne H, Condreay Lynn D

Abstract excerpt

Mutations in the YMDD motif of the hepatitis B virus (HBV) DNA polymerase result in reduced susceptibility of HBV to inhibition by lamivudine, at a cost in replication fitness. The mechanisms underlying the effects of YMDD mutations on replication fitness were investigated using both a cell-based...

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Identifiers

PMID: 11897582
DOI: 10.1128/AAC.46.4.1005-1013.2002
PMCID: PMC127103

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11897582-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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