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Article

In vitro characterization of the anti-hepatitis B virus activity and cross-resistance profile of 2',3'-dideoxy-3'-fluoroguanosine.

Antimicrobial agents and chemotherapy - 1 Mar 2006

Jacquard A-C, Brunelle M-N, Pichoud C, Durantel D, Carrouée-Durantel S, Trepo C, Zoulim F

Abstract excerpt

The fluorinated guanosine analog 2',3'-dideoxy-3'-fluoroguanosine (FLG) was shown to inhibit wild-type (wt) hepatitis B virus (HBV) replication in a human hepatoma cell line permanently expressing HBV. Experiments performed in the duck model of HBV infection also showed its in vivo antiviral activity. In this study, we investigated the mechanism of inhibition of FLG on HBV replication and its profile of antiviral...

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Identifiers

PMID: 16495257
DOI: 10.1128/AAC.50.3.955-961.2006
PMCID: PMC1426422

Genes

FLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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