Article

Mutation in HBV RNA-dependent DNA polymerase confers resistance to lamivudine in vivo

1996-09-01

Abstract excerpt

The (-) enantiomer of 3'-thiacytidine (lamivudine) has been found to be a potent inhibitor of hepatitis B virus (HBV) and human immunodeficiency virus (HIV) replication. Mutation of methionine to valine or isoleucine at the YMDD (tyrosine, methionine, aspartate, aspartate) motif of the HIV reverse transcriptase has been shown to be responsible for lamivudine resistance in HIV. The hepadnaviruses also have the YMDD...

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Literature Corpus work: 246fde9d-7953-55ad-8acb-1341ad8fce20
DOI: 10.1053/jhep.1996.v24.pm0008781348

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