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Article

Decreased infectivity of nucleoside analogs-resistant hepatitis B virus mutants.

Journal of hepatology - 1 Jun 2012

Billioud Gaëtan, Pichoud Christian, Parent Romain, Zoulim Fabien

Abstract excerpt

BACKGROUND & AIMS: To understand the mechanisms of emergence and selection of HBV polymerase variants, which may also harbor mutations in the overlapping envelope protein, we analyzed the in vitro virus production and infectivity of the main viral mutants resistant to lamivudine and adefovir. METHODS: HBV-resistant mutants (rtL180M+M204V, rtV173L+L180M+M204V, rtM204I, rtL180M+M204I, rtN236T, rtA181V,...

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Identifiers

PMID: 22314422
DOI: 10.1016/j.jhep.2012.01.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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