Article
A quantitative assay for assessing allelic proportions by iterative gap ligation.
Nucleic acids research - 15 Feb 1998
Stewart J, Kozlowski P, Sowden M, Messing E, Smith H C
Abstract excerpt
A variety of techniques are currently available for detecting point mutations in DNA. These techniques are frequently not sensitive enough to be applied as quantitative assays in evaluation of relative occurrence of alleles in cases of polymorphism or when variations in allelic gene expression ar...
Topics
- Alleles
- Base Sequence
- DNA
- DNA Ligases
- DNA Primers
- Evaluation Studies as Topic
- Genes, Wilms Tumor
- Genetic Techniques
- Humans
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Sensitivity and Specificity