Article
Detecting Allelic Expression Imbalance at Candidate Genes Using 5' Exonuclease Genotyping Technology.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2015
Gahan Jillian M, Byrne Mikaela M, Hill Matthew, Quinn Emma M, Murphy Ross T, Anney Richard J L, Ryan Anthony W
Abstract excerpt
Genetic variation along the length of a chromosome can influence the transcription of a gene. In a heterozygous individual, this may lead to one chromosome producing different levels of RNA, compared to its paired chromosome, for a given gene. Allelic differences in gene expression can offer insight into the role of variation in transcription, and subsequently infer a route to conferring disease risk. This...
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