Article
Budding yeast Cdc20: a target of the spindle checkpoint.
Science (New York, N.Y.) - 13 Feb 1998
Hwang L H, Lau L F, Smith D L, Mistrot C A, Hardwick K G, Hwang E S, Amon A, Murray A W
Abstract excerpt
The spindle checkpoint regulates the cell division cycle by keeping cells with defective spindles from leaving mitosis. In the two-hybrid system, three proteins that are components of the checkpoint, Mad1, Mad2, and Mad3, were shown to interact with Cdc20, a protein required for exit from mitosis. Mad2 and Mad3 coprecipitated with Cdc20 at all stages of the cell cycle. The binding of Mad2 depended on Mad1 and...
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