Article
Association of HLA-DR, -DQ genotype and CTLA-4 gene polymorphism with Graves' disease in Japanese children.
Hormone research - 1 Jan 2005
Iwama Saika, Ikezaki Ayako, Kikuoka Noriko, Kim Hye-Sook, Matsuoka Hisafumi, Yanagawa Tatsuo, Sato Hirokazu, Hoshi Mari, Sakamaki Tateo, Sugihara Shigetaka
Abstract excerpt
OBJECTIVE: Childhood onset Graves' disease (GD) has been documented to be clinically distinct from adult onset GD, and an association with the genes encoding HLA and CTLA-4 (cytotoxic T lymphocyte antigen-4) has been reported in both Caucasian and Japanese adult GD patients. The aim of this study was to determine whether HLA-DR, -DQ and CTLA-4 are associated with childhood onset GD in Japanese individuals....
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