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Article

Development of recombinant human prolactin receptor antagonists by molecular mimicry of the phosphorylated hormone.

Endocrinology - 1 Feb 1998

Chen T J, Kuo C B, Tsai K F, Liu J W, Chen D Y, Walker A M

Abstract excerpt

Previous studies have demonstrated that naturally phosphorylated PRL antagonizes the growth-promoting effects of unmodified PRL in two different PRL-responsive cell lines. In this study our aim was to produce a molecular mimic of phosphorylated PRL by substituting a fairly bulky, negatively charged amino acid (glutamate or aspartate) for the normally phosphorylated serine [serine 179 in human PRL (hPRL)]. In...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9449632
DOI: 10.1210/endo.139.2.5758

Genes

PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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