Article
Identification of a gain-of-function mutation of the prolactin receptor in women with benign breast tumors.
Proceedings of the National Academy of Sciences of the United States of America - 23 Sept 2008
Bogorad Roman L, Courtillot Carine, Mestayer Chidi, Bernichtein Sophie, Harutyunyan Lilya, Jomain Jean-Baptiste, Bachelot Anne, Kuttenn Frédérique, Kelly Paul A, Goffin Vincent, Touraine Philippe
Abstract excerpt
There is currently no known genetic disease linked to prolactin (Prl) or its receptor (PrlR) in humans. Given the essential role of this hormonal system in breast physiology, we reasoned that genetic anomalies of Prl/PrlR genes may be related to the occurrence of breast diseases with high proliferative potential. Multiple fibroadenomas (MFA) are benign breast tumors which appear most frequently in young women,...
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