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Article

Structural and thermodynamic bases for the design of pure prolactin receptor antagonists: X-ray structure of Del1-9-G129R-hPRL.

The Journal of biological chemistry - 9 Nov 2007

Jomain Jean-Baptiste, Tallet Estelle, Broutin Isabelle, Hoos Sylviane, van Agthoven Jan, Ducruix Arnaud, Kelly Paul A, Kragelund Birthe B, England Patrick, Goffin Vincent

Abstract excerpt

Competitive antagonists of the human prolactin (hPRL) receptor are a novel class of molecules of potential therapeutic interest in the context of cancer. We recently developed the pure antagonist Del1-9-G129R-hPRL by deleting the nine N-terminal residues of G129R-hPRL, a first generation partial antagonist. We determined the crystallographic structure of Del1-9-G129R-hPRL, which revealed no major change compared...

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Identifiers

PMID: 17785459
DOI: 10.1074/jbc.M704364200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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