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Article

Conversion of human interleukin-4 into a high affinity antagonist by a single amino acid replacement.

The EMBO journal - 1 Sept 1992

Kruse N, Tony H P, Sebald W

Abstract excerpt

Interleukin-4 (IL-4) represents a prototypic lymphokine (for a recent review see Paul, 1991). It promotes differentiation of B-cells and the proliferation of T- and B-cell, and other cell types of the lymphoid system. An antagonist of human IL-4 was discovered during the studies presented here after Tyr124 of the recombinant protein had been substituted by an aspartic acid residue. This IL-4 variant, Y124D, bound...

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Identifiers

PMID: 1387082
DOI: 10.1002/j.1460-2075.1992.tb05401.x
PMCID: PMC556857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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