Article
Conversion of human interleukin-4 into a high affinity antagonist by a single amino acid replacement.
The EMBO journal - 1 Sept 1992
Kruse N, Tony H P, Sebald W
Abstract excerpt
Interleukin-4 (IL-4) represents a prototypic lymphokine (for a recent review see Paul, 1991). It promotes differentiation of B-cells and the proliferation of T- and B-cell, and other cell types of the lymphoid system. An antagonist of human IL-4 was discovered during the studies presented here af...
Topics
- Antigens, Differentiation, B-Lymphocyte
- B-Lymphocytes
- Binding, Competitive
- Cell Differentiation
- Cells, Cultured
- Escherichia coli
- Genetic Variation
- Humans
- Interleukin-4
- Lymphocyte Activation
- Mutagenesis, Site-Directed
- Receptors, Fc
- Receptors, IgE
- Receptors, Interleukin-4
- Receptors, Mitogen
- Signal Transduction
- T-Lymphocytes