Article
Dominant negative and cooperative effects of mutant forms of prolactin receptor.
Molecular endocrinology (Baltimore, Md.) - 1 Jul 1997
Perrot-Applanat M, Gualillo O, Pezet A, Vincent V, Edery M, Kelly P A
Abstract excerpt
In addition to a long form of 591 amino acids (aa), two other forms of PRL receptor (PRLR), differing in the length of their cytoplasmic domains, have been identified in the rat. The Nb2 form, lacking 198 aa in the cytoplasmic domain, is able to transmit a lactogenic signal similar to the long fo...
Topics
- Animals
- CHO Cells
- Cell Differentiation
- Cell Membrane
- Cricetinae
- Cytoplasm
- Fibroblasts
- Humans
- Janus Kinase 2
- Mutation
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Rats
- Receptors, Prolactin
- Recombinant Proteins
- Signal Transduction
- Solubility