Article
Dominant negative and cooperative effects of mutant forms of prolactin receptor.
Molecular endocrinology (Baltimore, Md.) - 1 Jul 1997
Perrot-Applanat M, Gualillo O, Pezet A, Vincent V, Edery M, Kelly P A
Abstract excerpt
In addition to a long form of 591 amino acids (aa), two other forms of PRL receptor (PRLR), differing in the length of their cytoplasmic domains, have been identified in the rat. The Nb2 form, lacking 198 aa in the cytoplasmic domain, is able to transmit a lactogenic signal similar to the long form, whereas the short form of 291 aa is inactive. The ability of PRL to activate the promoter of the beta-casein gene...
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